Last data update: May 13, 2024. (Total: 46773 publications since 2009)
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Query Trace: Tegomoh B[original query] |
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Genomic surveillance of SARS-CoV-2 reveals highest severity and mortality of delta over other variants: evidence from Cameroon
Fokam J , Essomba RG , Njouom R , Okomo MA , Eyangoh S , Godwe C , Tegomoh B , Otshudiema JO , Nwobegahay J , Ndip L , Akenji B , Takou D , Moctar MMM , Mbah CK , Ndze VN , Maidadi-Foudi M , Kouanfack C , Tonmeu S , Ngono D , Nkengasong J , Ndembi N , Bissek AZK , Mouangue C , Ndongo CB , Epée E , Mandeng N , Kamso Belinga S , Ayouba A , Fernandez N , Tongo M , Colizzi V , Halle-Ekane GE , Perno CF , Ndjolo A , Ndongmo CB , Shang J , Esso L , de-Tulio O , Diagne MM , Boum Y 2nd , Mballa GAE , Njock LR . Sci Rep 2023 13 (1) 21654 While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report the dynamics of SARS-CoV-2 lineages from March 2020 to March 2022 in Cameroon. Of the 760 whole-genome sequences successfully generated by the national genomic surveillance network, 74% were viral sub-lineages of origin and non-variants of concern, 15% Delta, 6% Omicron, 3% Alpha and 2% Beta variants. The pandemic was driven by SARS-CoV-2 lineages of origin in wave 1 (16 weeks, 2.3% CFR), the Alpha and Beta variants in wave 2 (21 weeks, 1.6% CFR), Delta variants in wave 3 (11 weeks, 2.0% CFR), and omicron variants in wave 4 (8 weeks, 0.73% CFR), with a declining trend over time (p = 0.01208). Even though SARS-CoV-2 heterogeneity did not seemingly contribute to the breadth of transmission, the viral lineages of origin and especially the Delta variants appeared as drivers of COVID-19 severity in Cameroon. |
Investigation of a SARS-CoV-2 B.1.1.529 (Omicron) Variant Cluster - Nebraska, November-December 2021.
Jansen L , Tegomoh B , Lange K , Showalter K , Figliomeni J , Abdalhamid B , Iwen PC , Fauver J , Buss B , Donahue M . MMWR Morb Mortal Wkly Rep 2021 70 (5152) 1782-1784 The B.1.1.529 (Omicron) variant of SARS-CoV-2 (the virus that causes COVID-19) was first detected in specimens collected on November 11, 2021, in Botswana and on November 14 in South Africa;* the first confirmed case of Omicron in the United States was identified in California on December 1, 2021 (1). On November 29, the Nebraska Department of Health and Human Services was notified of six probable cases(†) of COVID-19 in one household, including one case in a man aged 48 years (the index patient) who had recently returned from Nigeria. Given the patient's travel history, Omicron infection was suspected. Specimens from all six persons in the household tested positive for SARS-CoV-2 by reverse transcription-polymerase chain reaction (RT-PCR) testing on December 1, and the following day genomic sequencing by the Nebraska Public Health Laboratory identified an identical Omicron genotype from each specimen (Figure). Phylogenetic analysis was conducted to determine if this cluster represented an independent introduction of Omicron into the United States, and a detailed epidemiologic investigation was conducted. This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.(§). |
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